Table 2.

Related TEAEs to dalantercept in ≥10% patients overall

Preferred term0.6 mg/kg (n = 6) n (%)0.9 mg/kg (n = 9) n (%)1.2 mg/kg (n = 14) n (%)Overall (n = 29) n (%)
Fatigue4 (66.7)5 (55.6)10 (71.4)19 (65.5)
Diarrhea2 (33.3)4 (44.4)6 (42.9)12 (41.4)
Peripheral edema03 (33.3)6 (42.9)9 (31.0)
Nausea2 (33.3)3 (33.3)3 (21.4)8 (27.6)
Blood creatinine increased006 (42.9)6 (20.7)
Epistaxis1 (16.7)1 (11.1)4 (28.6)6 (20.7)
Pericardial effusion02 (22.2)4 (28.6)6 (20.7)
Telangiectasia05 (55.6)1 (7.1)6 (20.7)
Arthralgia02 (22.2)3 (21.4)5 (17.2)
Decreased appetite005 (35.7)5 (17.2)
Dysphonia1 (16.7)1 (11.1)3 (21.4)5 (17.2)
Hypothyroidism02 (22.2)3 (21.4)5 (17.2)
Weight decreased1 (16.7)1 (11.1)3 (21.4)5 (17.2)
Abdominal pain01 (11.1)3 (21.4)4 (13.8)
Anemia01 (11.1)3 (21.4)4 (13.8)
Constipation1 (16.7)3 (33.3)04 (13.8)
Gingival bleeding02 (22.2)2 (14.3)4 (13.8)
Muscle spasms2 (33.3)02 (14.3)4 (13.8)
Palmar-plantar erythrodysesthesia syndrome01 (11.1)3 (21.4)4 (13.8)
Pleural effusion01 (11.1)3 (21.4)4 (13.8)
Thrombocytopenia01 (11.1)3 (21.4)4 (13.8)
Headache01 (11.1)2 (14.3)3 (10.3)
Hypertension02 (22.2)1 (7.1)3 (10.3)
Hypophosphatemia1 (16.7)02 (14.3)3 (10.3)
Rash02 (22.2)1 (7.1)3 (10.3)