Table 4.

Univariable (UVA) and multivariable (MVA) models of association of p53 and clinicopathologic risk factors for prediction of metastasis in post-biochemical recurrence cohort

UVAMVA
VariablesHR (95% CI)PHR (95% CI)P
Patient age at RP0.99 (0.95–1.02)0.470.99 (0.95–1.03)0.55
Log2 preoperative PSA (ng/mL)1.05 (0.83–1.32)0.680.97 (0.76–1.23)0.79
RP Gleason score ≤3+4Ref1Ref1
RP Gleason score 4+32.41 (1.18–4.94)0.022.43 (1.15–5.13)0.02
RP Gleason score 84.27 (2.33–7.81)<0.0014.13 (2.24–7.59)<0.001
RP Gleason score ≥94.84 (2.78–8.41)<0.0013.99 (2.27–7)<0.001
Positive surgical margins0.73 (0.46–1.16)0.180.71 (0.45–1.11)0.14
Extraprostatic extension1.72 (0.93–3.18)0.090.87 (0.45–1.7)0.68
Seminal vesicle invasion2.91 (1.87–4.53)<0.0012.2 (1.35–3.57)0.001
Lymph node invasion1.78 (1.12–2.81)0.010.95 (0.55–1.63)0.86
p53 normalRef1Ref1
p53 nuclear accumulation4.14 (2.41–7.11)<0.0012.55 (1.1–5.91)0.03