Table 3.

Univariable and multivariable Cox regression analysis for DMFS of node-positive patients receiving FAC/FEC adjuvant chemotherapy (adjuvant cohort)

UnivariableMultivariable
CharacteristicEvents/NHR (95% CI)PEvents/NHR (95% CI)P
Age (at diagnosis)
 ≤4024/33119/251
 >40–5039/660.67 (0.40–1.11)0.123/440.34 (0.17–0.67)0.002
 >5010/190.48 (0.23–1.01)0.05410/170.78 (0.33–1.85)0.6
Menopausal status (at diagnosis)
 Pre66/108146/781
 Post7/100.96 (0.44–2.10)0.96/80.93 (0.33–2.60)0.9
Tumor size
 T1 (≤2 cm)14/28112/211
 T2 (>2–5 cm)43/681.70 (0.93–3.12)0.0931/531.15 (0.54–2.45)0.7
 T3/4 (>5 cm)14/192.16 (1.02–4.55)0.0439/121.67 (0.62–4.49)0.3
Nodal status
 1–341/7311
 >332/451.48 (0.93–2.36)0.11.39 (0.76–2.55)0.3
Grade (GGI)
 17/1616/131
 224/381.84 (0.79–4.28)0.222/341.37 (0.50–3.74)0.5
 328/442.03 (0.88–4.64)0.124/391.21 (0.44–3.34)0.7
ER status
 Negative22/34117/261
 Positive51/840.76 (0.46–1.26)0.335/601.68 (0.55–5.13)0.4
PR status
 Negative22/32120/301
 Positive44/740.64 (0.38–1.07)0.132/560.41 (0.13–1.25)0.1
HER2 status
 Balanced48/85142/741
 Amplified12/142.54 (1.33–4.85)0.00410/122.04 (0.92–4.54)0.1
mtDNA
 High39/56126/381
 Low34/620.57 (0.36–0.90)0.01726/480.46 (0.24–0.89)0.020
  • NOTE: In the multivariable model, analysis was limited to 86 patients (52 events) with no missing values.