Table 3.

Univariable (UVA) and multivariable (MVA) models of association of p53 and clinicopathologic risk factors with metastasis in intermediate/high risk radical prostatectomy cohort

UVAMVA
VariablesHR (95% CI)PHR (95% CI)P
Patient age at RP0.99 (0.96–1.02)0.521.00 (0.96–1.04)0.93
Log2 preoperative PSA (ng/mL)1.23 (0.94–1.61)0.131.10 (0.84–1.42)0.49
RP Gleason score ≤3+4Ref1ref1
RP Gleason score 4+31.90 (0.89–4.04)0.11.81 (0.83–3.95)0.14
RP Gleason score 84.70 (2.24–9.89)<0.0013.09 (1.26–7.56)0.01
RP Gleason score ≥913.00 (7.19–23.51)<0.0017.12 (3.82–13.29)<0.001
Positive surgical margins2.08 (1.34–3.24)0.0011.79 (1.07–2.99)0.03
Extraprostatic extension3.95 (2.17–7.19)<0.0011.43 (0.72–2.86)0.31
Seminal vesicle invasion7.96 (5.04–12.58)<0.0013.32 (1.91–5.77)<0.001
Lymph node invasion6.66 (4.12–10.75)<0.0012.63 (1.43–4.83)0.002
p53 normalRef1Ref1
p53 nuclear accumulation4.84 (2.44 -9.61)<0.0011.87 (0.83–4.23)0.13