Univariable (UVA) and multivariable (MVA) models of association of p53 and clinicopathologic risk factors with metastasis in intermediate/high risk radical prostatectomy cohort
| UVA | MVA | |||
|---|---|---|---|---|
| Variables | HR (95% CI) | P | HR (95% CI) | P |
| Patient age at RP | 0.99 (0.96–1.02) | 0.52 | 1.00 (0.96–1.04) | 0.93 |
| Log2 preoperative PSA (ng/mL) | 1.23 (0.94–1.61) | 0.13 | 1.10 (0.84–1.42) | 0.49 |
| RP Gleason score ≤3+4 | Ref | 1 | ref | 1 |
| RP Gleason score 4+3 | 1.90 (0.89–4.04) | 0.1 | 1.81 (0.83–3.95) | 0.14 |
| RP Gleason score 8 | 4.70 (2.24–9.89) | <0.001 | 3.09 (1.26–7.56) | 0.01 |
| RP Gleason score ≥9 | 13.00 (7.19–23.51) | <0.001 | 7.12 (3.82–13.29) | <0.001 |
| Positive surgical margins | 2.08 (1.34–3.24) | 0.001 | 1.79 (1.07–2.99) | 0.03 |
| Extraprostatic extension | 3.95 (2.17–7.19) | <0.001 | 1.43 (0.72–2.86) | 0.31 |
| Seminal vesicle invasion | 7.96 (5.04–12.58) | <0.001 | 3.32 (1.91–5.77) | <0.001 |
| Lymph node invasion | 6.66 (4.12–10.75) | <0.001 | 2.63 (1.43–4.83) | 0.002 |
| p53 normal | Ref | 1 | Ref | 1 |
| p53 nuclear accumulation | 4.84 (2.44 -9.61) | <0.001 | 1.87 (0.83–4.23) | 0.13 |