Univariable | Multivariable | ||||
---|---|---|---|---|---|

Variables | No. of alterations median, (95% CI) | P | B coef. | t-statistic^{a} | P |

Smoking status^{b} | 0.030 | 0.865 | 1.754 | 0.083 | |

Yes (N = 50) | 2 (2–3) | ||||

No (N = 36) | 1.5 (1–3) | ||||

Gender | 0.643 | — | — | — | |

Women (N = 58) | 2 (1–3) | ||||

Men (N = 30) | 2 (1–3) | ||||

Age at diagnosis^{c} | 0.232 | — | — | — | |

≤66 years old (N = 41) | 2 (1–3) | ||||

>66 years old (N = 47) | 2 (1–3) | ||||

TP53 alteration(s) detected | 0.001 | 1.599 | 3.268 | 0.002 | |

Yes (N = 39) | 3 (2–4) | ||||

No (N = 49) | 1 (1–2) | ||||

EGFR alteration(s) detected | 0.113 | — | — | — | |

Yes (N = 24) | 3 (2–4) | ||||

No (N = 64) | 2 (1–2) | ||||

MET alteration(s) detected | 0.001 | 1.633 | 2.346 | 0.021 | |

Yes (N = 13) | 3 (3–6) | ||||

No (N = 75) | 2 (1–2) | ||||

Brain metastasis | 0.195 | — | — | — | |

Yes (N = 34) | 2.5 (2–3) | ||||

No (N = 54) | 2 (1–2) | ||||

Bone metastasis | 0.843 | — | — | — | |

Yes (N = 42) | 2 (2–3) | ||||

No (N = 46) | 1.5 (1–2) | ||||

Liver metastasis | 0.831 | — | — | — | |

Yes (N = 19) | 2 (1–4) | ||||

No (N = 69) | 2 (1.5–3) | ||||

Lymph node metastasis | 0.107 | — | — | — | |

Yes (N = 45) | 2 (2–3) | ||||

No (N = 43) | 2 (1–2) |

NOTE: Only variables with

*N*> 10 patients with the alteration were included. Variables with*P*≤ 0.05 in the univariable analysis were included in the multivariable model.*P*values were calculated using linear regression models (univariable and multivariable analyses).↵

^{a}The*t*-statistic is the ratio of the*B*coefficient and the standard error; the higher the value, the greater is the importance of the variable in the model. 95% CI, 95% confidence interval.↵

^{b}No smoking history available for 2 patients.↵

^{c}Cutoff of 66 years old corresponds to the median (Table 1).