Table 2.

Diagnostic performance of HSI, autofluorescence imaging, 2-NBDG fluorescence imaging, and proflavine fluorescence imaging using the intra-patient classification method

Cancer siteImaging methodAUCAccuracySensitivitySpecificity
Oral cavity (n = 12)HSI0.95 ± 0.0589% ± 8%90% ± 7%90% ± 8%
Autofluorescence0.82 ± 0.2081% ± 16%80% ± 16%80% ± 19%
2-NBDG0.83 ± 0.1479% ± 14%79% ± 15%79% ± 14%
Proflavine0.68 ± 0.1866% ± 14%64% ± 16%69% ± 15%
Gland (6 thyroid, 1 parotid)HSI0.96 ± 0.0491% ± 7%91% ± 8%93% ± 6%
Autofluorescence0.72 ± 0.3167% ± 33%80% ± 20%71% ± 35%
2-NBDG0.84 ± 0.1880% ± 17%78% ± 19%82% ± 16%
Proflavine0.80 ± 0.2378% ± 21%73% ± 26%82% ± 15%
Larynx and pharynx (n = 3)HSI0.97 ± 0.0394% ± 4%95% ± 4%90% ± 7%
Autofluorescence0.74 ± 0.2674% ± 21%74% ± 28%79% ± 22%
2-NBDG0.97 ± 0.0492% ± 7%92% ± 8%92% ± 5%
Proflavine0.79 ± 0.2377% ± 20%77% ± 20%74% ± 23%
Paranasal and nasal (n = 3)HSI0.96 ± 0.0290% ± 5%90% ± 5%90% ± 4%
Autofluorescence0.81 ± 0.1176% ± 10%79% ± 8%72% ± 14%
2-NBDG0.76 ± 0.1868% ± 19%64% ± 20%79% ± 7%
Proflavine0.80 ± 0.0873% ± 6%69% ± 11%79% ± 2%