Table 2.

Univariate and multivariate Cox proportional regression analysis of factors associated with intrahepatic recurrence and lung metastasis

Intrahepatic recurrenceLung metastasis
Univariate analysisMultivariate analysisUnivariate analysisMultivariate analysis
VariablesHR (95% CI)PHR (95% CI)PHR (95% CI)PHR (95% CI)P
Age (>50 y vs. ≤50 y)2.17 (0.92–5.12)0.077N.A.N.A.1.04 (0.25–4.36)0.954N.A.N.A.
Gender (male vs. female)0.63 (0.24–1.68)0.362N.A.N.A.0.51 (0.06–4.17)0.532N.A.N.A.
HBsAg (Positive vs. Negative)0.63 (0.41–2.51)0.937N.A.N.A.0.91 (0.18–4.49)0.906N.A.N.A.
Liver cirrhosis (Yes vs. No)1.26 (0.58–2.74)0.560N.A.N.A.2.23 (0.45–11.05)0.326N.A.N.A.
AFP (>20 ng/mL vs. ≤20 ng/mL)3.25 (1.36–7.77)0.0082.01 (0.78–5.19)0.1502.17 (0.43–10.73)0.344N.A.N.A.
Tumor number (multiple vs. single)1.08 (0.46–2.65)0.873N.A.N.A.0.56 (0.07–4.55)0.587N.A.N.A.
Tumor size (>5 cm vs. ≤5 cm)1.44 (0.61–3.40)0.410N.A.N.A.2.78 (0.34–22.61)0.339N.A.N.A.
Satellite lesion (yes vs. no)1.39 (0.64–3.02)0.401N.A.N.A.0.79 (0.16–3.91)0.772N.A.N.A.
Vascular invasion (yes vs. no)2.29 (1.02–5.11)0.0440.73 (0.28–1.92)0.5331.40 (0.34–5.87)0.644N.A.N.A.
Edmondson stage (III–IV vs. I–II)1.21 (0.57–2.56)0.627N.A.N.A.3.25 (0.66–16.11)0.149N.A.N.A.
BCLC stage (B+C vs. 0+A)0.53 (1.81–1.53)0.240N.A.N.A.0.45 (0.06–3.62)0.449N.A.N.A.
PV CTC (≥2 vs. <2)7.87 (2.87–21.59)<0.0010.77 (0.14–5.19)0.765N.A.N.A.N.A.N.A.
PA CTC (≥1 vs. <1)5.55 (2.34–13.19)<0.0012.54 (0.87–7.42)0.089N.A.N.A.N.A.N.A.
HV CTC (≥18 vs. <18)N.A.N.A.N.A.N.A.54.99 (6.71–450.63)<0.0010.59 (0.04–9.54)0.712
IHIVC CTC (≥18 vs. <18)N.A.N.A.N.A.N.A.16.47 (3.31–81.92)0.0010.67 (0.10–4.40)0.680
PV CTC with the presence of CTM
  • 1: CTC<2 without CTM

  • 2: CTC≥2 without CTM

  • 3: CTC≥2 with CTM

4.33 (2.54–7.38)<0.0013.48 (1.40–8.61)0.007N.A.N.A.N.A.N.A.
HV CTC with the presence of CTM
  • 1: CTC<18 without CTM

  • 2: CTC≥18 without CTM

  • 3: CTC≥18 with CTM

N.A.N.A.N.A.N.A.28.76 (4.54–182.38)<0.00142.20 (3.73–477.80)0.003
  • NOTE: Clinicopathologic variables were adopted for their prognostic significance by univariate analyses.

  • Abbreviations: HBsAg, hepatitis B surface antigen; N.A., not applicable.