Table 2.

Cabazitaxel pharmacokinetics

Cabazitaxel PK parametersC1 (caba)C2 (caba+enza)C3 (caba + enza)Difference C3/C1 % (95% CI)Pa
AUC0–24h; ng*h/mL (CV%)234 (19)182 (26)181 (34)−22 (−9 till −34)0.005
Cmax; ng/mL (CV%)138 (39)96 (49)96 (20)−30 (−42 till −16)0.001
t1/2; h (CV%)22 (87)14 (41)18 (79)−18 (−59 till 64)0.552
  • Abbreviations: AUC0–24h, area under the curve for 24 hours; C1/2/3, cycle 1/2/3; caba, cabazitaxel; CI, confidence Interval, expressed as geomean; Cmax, max concentration, expressed as geomean; CV%, coefficient of variation; enza, enzalutamide; PK, pharmacokinetics; t1/2, half-life, expressed as geomean.

  • aComparison between cycle 1 and cycle 3.