Table 1.

Associations of clinical characteristics with CTCs detected in different anatomic vascular compartments of HCC patients

Systemic circulationHepatic circulation
No. of CTCsNo. of CTCs
PVPAHVIHIVCPoV
CharacteristicsNo. of patients (n = 73)Median (range)PMedian (range)PMedian (range)PMedian (range)PMedian (range)P
Age0.0150.1590.5790.9490.391
 ≤50572 (0–26)0 (0–7)6 (0–31)0 (0–5)0 (0–6)
 >50162 (0–5)0.5 (0–11)6 (0–30)0 (0–6)1 (0–8)
Gender0.6000.1300.1720.1230.466
 Male291 (0–14)0 (0–11)8 (0–31)0 (0–5)1 (0–8)
 Female443 (0–26)0 (0–3)5 (0–21)0 (0–6)1 (0–4)
HBsAg0.7800.6830.6890.3110.211
 Negative173 (0–11)0 (0–5)6 (0–31)1 (0–6)2 (0–8)
 Positive561.5 (0–26)0 (0–11)6 (0–30)0 (0–6)1 (0–7)
Liver cirrhosis0.8200.2980.4160.9450.839
 No313 (0–13)0 (0–5)6 (0–31)0 (0–5)1 (0–8)
 Yes421.5 (0–26)0.5 (0–11)7.5 (0–30)0 (0–6)1 (0–7)
AFP0.0200.1270.5730.5460.748
 ≤20301 (0–11)0 (0–6)6.5 (0–31)0 (0–6)1 (0–7)
 >20433 (0–26)1 (0–11)6 (0–30)0 (0–6)1 (0–8)
Tumor number0.2280.5950.1881.0000.932
 Single581.5 (0–26)0 (0–11)5.5 (0–31)0 (0–6)1 (0–8)
 Multiple153 (0–14)1 (0–7)9 (0–24)0 (0–5)1 (0–6)
Tumor size, cm0.0250.0640.0130.1410.020
 ≤5200 (0–7)0 (0–5)4.5 (0–26)0 (0–6)0 (0–3)
 >5533 (0–26)1 (0–11)8 (0–31)0 (0–6)1 (0–8)
Satellite lesion0.0630.0040.8640.4510.839
 No521 (0–26)0 (0–7)6 (0–31)0 (0–5)1 (0–8)
 Yes213 (0–10)2 (0–11)6 (0–26)0 (0–6)1 (0–5)
Microvascular invasion0.0440.0310.6720.9500.051
 No331 (0–10)0 (0–5)6 (0–31)0 (0–6)1 (0–7)
 Yes403 (0–26)1 (0–11)6 (0–30)0 (0–6)1.5 (0–8)
Edmondson stage0.4960.3720.5980.2550.087
 I–II371 (0–11)0 (0–6)6 (0–31)0 (0–6)0 (0–8)
 III–IV363 (0–26)1 (0–11)6 (0–30)0.5 (0–6)1.5 (0–6)
BCLC stage0.94203060.6700.3670.155
 0-A562 (0–26)0 (0–7)6.5 (0–31)0 (0–6)1 (0–7)
 B-C172 (0–14)1 (0–11)6 (0–24)0 (0–6)1 (0–8)
Intrahepatic recurrence<0.001<0.0010.0660.1870.113
 No451 (0–10)0 (0–6)6 (0–31)0 (0–6)1 (0–8)
 Yes284 (0–26)2.5 (0–11)8 (0–30)0.5 (0–6)1.5 (0–6)
Lung metastasis0.2560.985<0.0010.0010.439
 No652 (0–26)0 (0–11)6 (0–31)0 (0–6)1 (0–8)
 Yes83.5 (0–13)0 (0–5)22.5 (18–30)3.5 (0–6)2 (0–5)
  • NOTE: The bold text is indicative of a statistical significance (P value < 0.05).

  • Abbreviation: HBsAg, hepatitis B surface antigen.