Table 3.

Summary of PK parameters following oral administration of axitinib at 5-, 3-, or 2-mg twice-daily dosage

ParameterAxitinib, 5 mgAxitinib, 3 mgAxitinib, 2 mg
Evaluable subjects (N)2631
Treatment cycleCycle 2, n = 25Cycle 3, n = 2Cycle 3, n = 1
Cycle 3, n = 1Cycle 4, n = 1
PK parameters
 Tmax (h)a3 (0-4)4 (3-4)4
 Cmax (ng/mL)b36.6 (66)28.2 (49)22.2
 AUC(0-t) (ng*h/mL) b82.9 (69)57.6 (59)53.7
  • Tmax, time after dosing when maximum concentration was observed; Cmax, maximum concentration after dosing; AUC(0-t), area under the concentration versus time curve from the start of dose administration to the time after dosing at which the last quantifiable concentration was observed using the linear trapezoidal method.

  • aMedian (range) reported for Tmax.

  • bGeometric mean (coefficient of variation, %CV) reported for Cmax and AUC(0-t).