Table 2.

Adverse events

Highest AE grade/dose cohort
Adverse event# Subjects affected, total (%)# Subjects affected, 2 and 3 mcg/kg (%)0.25 mcg/kg0.5 mcg/kg1 mcg/kg2 mcg/kg3 mcg/kg
Injection site reaction14 (74)7 (70)11111
Chills13 (68)8 (80)11122
Anemia12 (63)7 (70)22222
Fever11 (58)10 (100)123
Hypotension10 (53)8 (80)122
Fatigue9 (47)6 (60)1112
Hypophosphatemia9 (47)5 (50)3332
Tachycardia7 (37)5 (50)1111
Vomiting7 (37)4 (40)21111
Hypoalbuminemia7 (37)4 (40)3212
Hypertension7 (37)3 (00)2331
Dry skin6 (32)5 (50)112
Nausea6 (32)3 (30)2111
Lymphopenia5 (26)5 (50)33
Elevated AST5 (26)4 (40)112
Diarrhea5 (26)3 (30)3111
  • NOTE: Adverse events occurring in 5 more subjects is shown.