Table 2.

H-scores for PD-L1, and B7x expression correlated with stage, lymph nodes, and mutational status

A. PD-L1 expression:
Discovery cohortPValidation cohortP
StageEarly (I + II)Advanced (III)0.004StageEarly (I + II)Advanced (III)0.0003
Mean H-score (SD)13 (40)49 (64)Mean H-score (SD)21 (55)64 (70)
Lymph nodeNegativePositive0.04Lymph nodeNegativePositive0.03
Mean H-score (SD)14 (42)25 (49)Mean H-score (SD)23 (58)40 (57)
MutationEGFRWT/WT0.03MutationEGFRWT/WT0.95
Mean H-score (SD)4 (17)29 (59)Mean H-score (SD)27 (46)23 (60)
B. B7x expression:
Discovery cohortPValidation cohortP
RaceHispanicNon-Hispanic0.1RaceHispanicNon-Hispanic0.36
Mean H-score (SD)51 (62)85 (78)Mean H-score (SD)48 (58)72 (72)
MutationEGFRWT/WT0.06MutationEGFRWT/WT0.55
Mean H-score (SD)108 (79)66 (72)Mean H-score (SD)71 (59)66 (69)
HistologyAdenoNon-Adeno0.0002HistologyAdenoNon-Adeno0.07
Mean H-score (SD)91 (77)(SQ + large) 34 (53)Mean H-score (SD)82 (72)(SQ + large) 55 (62)