Table 1.

Patient demographics and baseline clinical characteristics in Parts A, B, and C

Patients in Parts A and B (n = 90)Patients in Part C (n = 59)
Mean age (SD), years55.4 (10.8)56.7 (12.7)
Male:female, n51:392:57
Primary tumor location, n (%)
 Rectal/colorectal26 (29)NA
 Pleura7 (8)NA
 Lung6 (7)NA
 Cervix5 (6)9 (15)
 Colon5 (6)NA
 Ovary4 (4)6 (10)
 Breast4 (4)31 (53)
 Uterus010 (17)
 Othera33 (37)3 (5)
WHO performance status, n (%)
 038 (42)30 (51)
 152 (58)29 (43)
Prior anticancer regimens, n (%)
 0 regimens01 (2)
 1 regimen12 (13)6 (10)
 2 regimens27 (30)11 (19)
 ≥3 regimens51 (57)41 (70)
Mean number of regimens (SD)3.3 (2)5.0 (3)
  • Abbreviation: NA, not available.

  • aOther includes cancers that occurred in 1 or 2 patients.