Table 1.

Levels of SN38 in blood, tumor and normal organs after 1 dose of CPT-11 or SN38-TOA NPs

Blood (ng/ml)Tumor (ng/g)Liver (ng/g)Spleen (ng/g)Lung (ng/g)Kidney (ng/g)
SN38 levelsCPT-11SN38-TOA NPCPT-11SN38-TOA NPCPT-11SN38-TOA NPCPT-11SN38-TOA NPCPT-11SN38-TOA NPCPT-11SN38-TOA NP
4 hrs8 (± 5)4537 (± 978)147 (± 26)383 (± 18)1245 (± 101)169965 (± 13524)56 (± 8)122691 (± 26283)38 (± 16)1710 (± 1328)421 (± 81)1289 (± 378)
24 hrs<1221 (± 8)<10193 (± 17)201 (± 1)126266 (± 8573)5 (± 5)1262239 (± 18376)5 (± 4)1976 (± 497)13 (± 4)1171 (± 335)
72 hrs<125 (± 10)<10102 (± 18)6 (± 6)106890 (± 13106)4 (± 5)110360 (± 31374)<21445 (± 413)6 (± 11)664 (± 424)