Table 1.

Common uses and limitations of lymphoma cell lines and patient-derived xenograft models

Common uses/advantagesLimitations
Lymphoma cell lines
  • –Screening platforms

  • –High-throughput testing of new agents

  • –Changes in gene expression for discovery of biomarkers

  • –Test of drug combinations

  • –Genomic instability

  • –Possibility of modifying the characteristics of the cells

  • –Inability to study the interactions between lymphoma and microenvironment

Patient-derived xenografts
  • –May better represent the actual biology

  • –Can complement cell line experiments

  • –Lack of engraftment for indolent lymphomas

  • –Requirement of engraftment in immune- deficient mice