Table 3.

Univariate results of IHC markers associated with subsequent iIBC

DCIS cases (n = 185)DCIS controls (n = 420)
Characteristicsn (%)n (%)OR (95% CI)aPb
ER
 Negative35 (18.9)79 (18.8)1.00 (reference)
 Positive149 (80.5)341 (81.2)0.99 (0.63–1.55)0.95
 N/A1 (0.5)0 (0.0)
PR
 Negative74 (40.0)149 (35.5)1.00 (reference)
 Positive108 (58.4)264 (62.9)0.83 (0.57–1.20)0.31
 N/A3 (1.6)7 (1.7)
HER2
 Negative120 (64.9)310 (73.8)1.00 (reference)
 Positive62 (33.5)104 (24.8)1.56 (1.05–2.31)0.03
 N/A3 (1.6)6 (1.4)
Subtypes
 HR+ HER2115 (62.2)284 (67.6)1.00 (reference)
 HR+ HER2+33 (17.8)54 (12.9)1.50 (0.92–2.47)
 HR HER2+29 (15.7)50 (11.9)1.47 (0.87–2.49)
 HR HER25 (2.7)26 (6.2)0.44 (0.16–1.20)0.06
 N/A3 (1.6)6 (1.4)
p16
 Low90 (48.6)228 (54.3)1.00 (reference)
 High93 (50.3)187 (44.5)1.29 (0.90–1.85)0.16
 N/A2 (1.1)5 (1.2)
p53
 <30% positive cells100 (54.1)240 (57.1)1.00 (reference)
 30%–70% positive cells40 (21.6)61 (14.5)1.67 (1.01–2.77)
 >70% positive cells25 (13.5)58 (13.8)1.08 (0.62–1.87)
 Negative17 (9.2)58 (13.8)0.78 (0.43–1.40)0.13
 N/A3 (1.6)3 (0.7)
COX-2
 Low19 (10.3)106 (25.2)1.00 (reference)
 High161 (87.0)306 (72.9)2.97 (1.72–5.10)<0.001
 N/A5 (2.7)8 (1.9)
  • Abbreviation: N/A, not assessable (N/As were not included in the analysis).

  • aComparisons between DCIS cases and DCIS controls were made by univariate conditional logistic regression.

  • bFor variables with >2 categories, the P value for overall effect was calculated by Wald test; for variables with only two categories, the prob >chi2 was used.