Parameter | Base model | Covariate model |
---|---|---|

OFV | −36.58 | −42.63 |

K_{a} (h^{−1}) | 2.00 (114) | 2.10 (111) |

V/F (L) | 1,500 (16) | 1,500 (17) |

CL/F (L/hour) | 160 (15) | 160^{a} (14) |

B^{a} | 1.7 (44) | |

IIV of K_{a} (CV%) | 100 (310) | 100 (300) |

IIV of V/F (CV%) | 28 (70) | 26 (91) |

IIV of CL/F (CV%) | 48 (23) | 40 (36) |

Abbreviations: CL/F, apparent oral clearance; IIV, interindividual variability;

*K*_{a}, first-order absorption rate constant; OFV, objective function value; RSE, relative standard error of estimation; V/F, apparent volume of distribution.↵

^{a}CL/F = A + B × (GFR – 98), where A is the CL/F for a typical patient with glomerular filtration rate (GFR) of 98 mL/minute, and B represents the covariate effect of glomerular filtration rate.