Table 1.

DLBCL and MCL cell line characterization and venetoclax sensitivity

SubtypeSTR DNA fingerprintingp53 statusBCL-2/MYCVenetoclax IC50 (nmol/L)KA2237 IC50 (μmol/L)
DLBCL cell lines
1HFGCBYeswt+/+<19.85
2U2932ABC (DHL)YesNDDHL<149.6
3RCGCB (DHL)yesNDDHL<10.68
4OCI-LY10ABCYeswt±56.04
5McAGCBYeswt+/+511.78
6LRABCYeswt+/+52.27
7FNGCBYeswt+/+514.85
8OCI-LY19GCBYeswt+/+54.74
9CJGCB (DHL)YesmutDHL2011.5
10OCI-LY3ABCYeswt+/+258.34
11MSGCBYesmut±502.03
12SUDHL-10GCBYesND±501.45
13ToledoGCBYeswt±956.59
14SUDHL-4GCBYesmut±1000.47
15HBABCYesmut−/+1,00010.42
16LVP-03PM-LBCLyesND−/−1,000NA
17TMD-8ABCYesND−/+1,0004.31
18DBGCBYesmut+/+1,00012.08
19HTGCBYesND−/−1,0000.68
20HBL-1ABCYesND±2,0004.31
21MZGCBYeswt+/+2,50015.26
22LPABCYesmut−/−5,0005.77
23DSGCBYesmut−/−5,00028.17
24PfeifferGCBYesmut−/−5,00025.73
25DBrGCBYeswt−/−>10,00022.05
26BJABGCBYeswt−/+>10,0000.65
MCL cell lines
1Z-138BlastoidYeswt+/+<12.3
2MinoClassicYesmut+/+<15
3JVM-13ClassicYeswt+/+24.5
4REC-1BlastoidYesmut±2.51.0
5GrantaClassicYeswt+/+52.9
6Jeko-1ClassicYesmut+/+51.3
7DBsp53ClassicYeswt±85
8PF-1ClassicYeswt+/+100
9JMP-1BlastoidYeswt−/−500
10Maver-1ClassicYesmut+/+>10,0004.1
  • NOTE: Cell viability assays were performed to identify the venetoclax IC50 values. BCL-2 and MYC protein expression was analyzed by reverse-phase protein array.

  • Abbreviations: ABC, activated B cell-like; DHL, double-hit lymphoma; GCB, germinal center-derived B cell; mut, mutant; ND, no data; PM-BCL, primary mediastinal large B-cell lymphoma; STR, short-tandem repeats; wt, wild-type.