Table 1.

Characteristics of patients with CH mutations versus those without CH mutations reported on FM testing

CharacteristicsCHNo CHTotalP
Number1,1396181,757NA
Age (mean)60.055.458.4<0.001
Gender (% male)537 (47%)309 (50%)846 (48%)0.25
Tumor type<0.001
 Breast100 (9%)34 (6%)134 (8%)
 Gastrointestinal150 (13%)40 (6%)190 (11%)
 Genitourinary83 (7%)59 (10%)142 (8%)
 Gynecologic101 (9%)24 (3.9%)125 (7%)
 Lung293 (26%)102 (17%)395 (22%)
 Sarcoma77 (7%)105 (17%)182 (10%)
 Skin119 (10%)65 (11%)182 (10%)
 Other216 (19%)189 (31%)405 (23%)
  • NOTE: Genes include DNMT3A, TET2, ASXL1, TP53, ATM, CHEK2, CBL, JAK2, and SF3B1. Both UNC and MCC patients are included together. The total number of reports is included here because this number represents the total number of FM reports (14 patients had more than one report, from different biopsies taken on different days).

  • Abbreviation: CH, clonal hematopoiesis.