Table 3.

Multivariate logistic and Cox regression analyses of Somatic and Germline DDR Mutations genes

Logistic regressionCox regression
VariableAOR (95% CI)PAdjusted HRP
Somatic and germline DDR mutations
 Absent1 (reference)1 (reference)
 Present1.47 (1.04–2.06)0.050.37 (0.15–0.94)0.04
Gender
 Female1 (reference)1 (reference)
 Male1.27 (0.85–1.89)0.260.50 (0.18–1.37)0.18
Age at diagnosis0.99 (0.97–1.00)0.181.04 (0.99–1.10)0.15
Primary tumor site
 Head1 (reference)1 (reference)
 Body/Tail1.29 (0.78–2.11)0.330.24 (0.05–1.22)0.08
Family history of cancer, N (%)
 No1 (reference)1 (reference)
 Yes1.03 (0.74–1.42)0.871.29 (0.51–3.25)0.59
Pathological T Stage
 T1/T21 (reference)1 (reference)
 T31.10 (0.65–1.86)0.720.71 (0.13–3.75)0.69
Pathological N Stage
 N01 (reference)1 (reference)
 N11.00 (0.63–1.58)0.992.21 (0.67–7.25)0.19
Margin involvement at surgery
 No1 (reference)1 (reference)
 Yes0.88 (0.58–1.30)0.521.73 (0.59–5.04)0.32
CA 19–9, U/mL
 Normal1 (reference)1 (reference)
 Elevated1.05 (0.72–1.52)0.821.95 (0.64–5.93)0.24
Adjuvant chemotherapy
 No1 (reference)1 (reference)
 Yes1.04 (0.66–1.63)0.870.53 (0.14–2.05)0.47
  • Abbreviations: AOR, adjusted odds ratio; CA, carbohydrate antigen; HR, hazard ratio; N, node; T, tumor.