Table 2.

Extrapolation of pretargeted RIT dosimetry to humans; Absorbed dose estimations for the ICRP 89 adult man calculated from the biodistribution data of 5B1-TCO/225Ac-DOTA-PEG7-Tz in mice bearing BxPC3 xenografts; Full dosimetry data are provided in Supplementary Table S16

5B1-TCO + 225Ac-DOTA-PEG7-Tz
Hypothesis 1Hypothesis 2
Absorbed doseEquivalent doseEquivalent dose (SvRBE5)Absorbed doseEquivalent doseEquivalent dose (SvRBE5)
cGy/MBqmSvRBE5/MBq10.4 MBqcGy/MBqmSvRBE5/MBq5.3 MBq
Red marrow1.9596.080.99a1.3868.510.36
Kidneys1.9595.180.98107502326.6b
Liver3.04148.81.552.08103.30.55
Spleen3.26159.51.662.25111.00.59
  • aProjected dose-limiting organ for the pretargeting method according to the first hypothesis, taking into account an MTD of 1 SvRBE5 for the bone marrow.

  • bProjected dose-limiting organ for the pretargeting method according to the second hypothesis, taking into account an MTD of 27 SvRBE5 for the kidneys.