Table 1.

Clinicopathologic characteristics stratified for homologous recombination capacity

HR-deficientHR-proficient
n (%)n (%)P
Total6 (100)17 (100)
Age, years
 Mean ± SD70 ± 9.366 ± 10.60.431
Tumor
 Primary6 (100)17 (100)
 Recurrent0 (0)0 (0)
Histologic subtype
 Endometrioid0 (0)11 (65)0.014a
 Non-endometrioid6 (100)6 (35)
  Serous3 (50)1 (6)
  Carcinosarcoma3 (50)1 (6)
  Clear cell0 (0)2 (12)
  Dedifferentiated0 (0)2 (12)
Histologic grade
 1 + 20 (0)10 (59)0.019
 36 (100)7 (41)
FIGO 2009
 I2 (33)15 (88)0.021
 III/IV4 (67)2 (12)
Adnexal involvement
 Yes1 (17)2 (12)1.00
 No5 (83)15 (88)
LVSI
 Yes4 (67)3 (18)0.045
 No2 (33)14 (82)
PTEN-IHC
 Loss of expression1 (17)8 (47)0.340
 Normal expression5 (83)9 (53)
aCGH
 Copy number extremely high4 (67)1 (6)0.019b
 Copy number high2 (33)6 (35)
 Copy number low0 (0)10 (60)
TP53
 Mutation6 (100)7 (41)0.019
 No mutation0 (0)10 (59)
TCGA subgroups
TP536 (100)6 (35)0.014
 NSMP/POLE/MMRd0 (0)11 (65)
  • NOTE: Bolded P values are considered significant (P < 0.05). P values were calculated using the 2-sided Fisher exact test for the categorical variables and the unpaired t test for the difference in age.

  • Abbreviations: LVSI, lymphovascular space involvement; MMRd, mismatch repair deficient; NSMP, no specific molecular profile.

  • aEndometrioid versus non-endometrioid histology was compared.

  • bCopy number extremely high + copy number high versus copy number low was compared.