Table 3.

Effect of ADC threshold on biopsy rates by lesion subset

Lesions Recommended for Biopsy (BI-RADS 4 and 5)Lesions with ADC >ThresholdaReduction in biopsy rate using ADC threshold
NNmNB
Lesion groupTotalMalignantBenignnn/N (%)95% CIP
All lesions6728391414/67 (20.9%)11.2%–31.2%<0.0001
BI-RADS Assessment category
 BI-RADS 4 only6324391414/63 (22.2%)11.8%–32.8%<0.0001
 BI-RADS 5 only44000/4 (0%)1.0
Morphology
 Mass3814241111/38 (28.9%)15.9%–44.1%0.0001
 NME26121433/26 (11.5%)0%–25.9%0.066
 Size ≤ 10 mm30121877/30 (23.3%)9.1%–39.3%0.0022
 Size > 10 mm37162177/37 (18.9%)7.5%–33.3%0.0028
  • aADC threshold (ADC ≤ 1.53 × 10−3 mm2/s) identified to maintain 100% sensitivity.