Table 6.

Toxicity versus UGT1A1 metabolizer phenotype and alisertib trough concentration (Cmin) on day 4

EMI/E, I, P
Grade ≥2: No (n = 7)Grade ≥ 2: Yes (n = 9)Grade ≥ 2; No (n = 8)Grade ≥ 2: Yes (n = 8)
Alisertib, Cmin (μmol/L) mean ± SD0.81 ± 0.431.17 ± 1.152.25 ± 1.531.87 ± 0.82
Alisertib, Cmin (μmol/L) median (range)0.99 (0.2–1.24)0.53 (0.08–3.51)2.22 (0.6–5.65)1.80 (0.97–3.10)