Table 2.

Correlations between immunochemical reclassification and clinicopathological and molecular characteristics

Reclassification by IHC
No. of casesOCCCLikely HGSOCP value
Number63549
Clinicopathologic information
 Age
  <55343130.280
  ≥5529236
 Stage
  Early181710.430
  Advanced45378
 Residual tumor (cm)
  None313020.130
  <122144
  ≥115103
 Morphologic type
  Pure61533<0.001
  Mixed716
IHC
 WT1a
  Negative53530<0.001
  Positive909
  Uninterpretable110
 HNF1Ba
  Negative1688<0.001
  Positive47461
 NapsinAa
  Negative1239<0.001
  Positive21510
 TP53a
  Normal51510<0.001
  Abnormal1129
  Uninterpretable110
 ERa
  Negative49490<0.001
  Focal/diffuse1349
  Uninterpretable110
 ARID1A
  Present30219<0.001
  Absent or heterogeneous loss32320
  Uninterpretable110
 FOLR1
  ≤10%222200.021
  >10%41329
 IGF2BP3
  ≤90%453780.423
  >90%17161
  Uninterpretable110
 Ki67
  ≤10%302820.152
  >10%33267
 MMR genes
  Normal63549-
  Abnormal000
Mutational status
 ARID1A
  Wild type29209<0.001
  Mutant34340
 PIK3CA
  Wild type423390.023
  Mutant21210
 TP53
  Wild type49490<0.001
  Mutant1459
 PPP2R1A
  Wild type554690.588
  Mutant880
 KRAS
  Wild type554781.000
  Mutant871
  • NOTE: P values were calculated by Fisher exact test. Cases with uninterpretable results were excluded in each calculation. MMR genes include MLH1, MSH2, MSH6, and PMS2.

  • aProteins included in immunohistochemical algorithm for subtype determination.