Table 4.

Histopathologic features, tumor-infiltrating lymphocyte immunophenotype, and BM1/BM2 classification in BRAF-mutated class 2 and 3 patients

BRAF mut class 2 TOT = 11 N (%)BRAF mut class 3 TOT = 10 N (%)P
Grading
 Low6 (54)7 (70)0.659
 High5 (46)3 (30)
CK7
 Low (0–1)9 (100)10 (100)1
 High (2–3)0 (0)0 (0)
 NE20
CK20
 Low (0–1)2 (29)4 (40)1
 High (2–3)5 (71)6 (60)
 Discordant20
 NE20
CDX2
 Low (0–150)0 (0)3 (30)0.211
 High (≥150)10 (100)7 (70)
 Discordant10
 NE00
CD3/CD8
 Low (0–20)5 (56)10 (100)0.033
 High (>20)4 (44)0 (0)
 NE20
BM1/BM2 Classification
 BM15 (56)2 (33)0.608
 BM24 (44)4 (67)
 NA24
  • Abbreviations: NE, not evaluable; NA, not assessable.