Table 2A.

Guideline-recommended genomic biomarker positivity by sample type

Guideline-recommended biomarker positivity by sample typeTissue
PositiveNegativeTotal
cfDNAPositive482977
Negative12193205
Total60222282
  • NOTE: The NILE study met the primary endpoint of cfDNA noninferiority. cfDNA analysis identified one of the eight guideline-recommended biomarkers in 77 patients, while tissue analysis identified a guideline-recommended biomarker in 60 patients (P = 0.0001). For cfDNA, negative includes samples that were negative for the biomarkers of interest or those samples that were TND. For tissue, negative includes samples that were negative for all biomarkers of interest, QNS for all biomarkers, and/or biomarkers were not assessed.