Table 1.

Baseline patient characteristics

Phase IThyroid expansion
Characteristic(N = 26)(N = 13)
Age
 Median5960
 Range33–8232–74
Sex (%)
 Male14 (54)7 (54)
 Female12 (46)6 (46)
Race (%)
 White20 (77)11 (85)
 Black2 (8)0
 Asian2 (8)1 (8)
 Unknown or other2 (8)1 (8)
Previous regimens
 Median41
 Range0–130–5
 Radiation-based therapy1113
Treatment site (%)
 MD Anderson Cancer Center (Houston, TX)14 (54)11 (85)
 Johns Hopkins University (Baltimore, MD)12 (46)2 (15)
ECOG performance status (%)
 010 (38)2 (15)
 116 (62)11 (85)
Tumor histology (%)
 Thyroid subtype
  Papillary2 (8)6 (46)
  Follicular1 (4)5 (38)
  Hurthle cell01 (8)
  Poorly differentiated1 (4)1 (8)
  Carcinoma1 (4)
 Basal cell carcinoma1 (4)
 Cholangiocarcinoma2 (8)
 Colorectal cancer2 (8)
 Endometrial cancer1 (4)
 Maxillary sinus cancer1 (4)
 Melanoma4 (15)
 Merkel cell carcinoma1 (4)
 Ovarian cancer3 (12)
 Pancreatic ductal adenocarcinoma1 (4)
 Pancreatic islet cell tumor1 (4)
 Sarcoma2 (8)
 Serous papillary cystadenocarcinoma1 (4)
 Squamous cell base of tongue cancer1 (4)