Table 1.

Classification of BRAF mutations

BRAF classBRAF mutationKinase activityPotential targets
Class IV600RAS independentBRAFi or BRAFi/MEKi combination
Class IINon-V600RAS and RTK independentMEKi, ERKi, or paradoxical blocking BRAFi
Class IIIN581, D594No kinase activity, CRAF activationMEKi + RTKi
  • Abbreviations: BRAFi, BRAF inhibitor; ERKi, ERK inhibitor; MEKi, MEK inhibitor; RTKi, RTK inhibitor.