Table 3.

Treatment-emergent adverse events.

All patients, N = 339
Any adverse eventDrug-related
Gr 1-2Gr 3Gr 4Gr 5Any gradeGr 3-4
Any event122 (36)144 (43)36 (11)34 (10)308 (91)135 (40)
Abdominal pain41 (12)7 (2)1 (0.3)018 (5)3 (1)
Anemia38 (11)20 (6)0044 (13)12 (4)
Asthenia42 (12)6 (2)01 (0.3)40 (12)5 (2)
Constipation72 (21)3 (1)0015 (4)1 (0.3)
Cough55 (16)0007 (2)0
Decreased appetite96 (28)7 (2)0053 (16)3 (1)
Dyspnea78 (23)5 (2)01 (0.3)33 (10)0
Edema peripheral97 (29)7 (2)0089 (26)6 (2)
Fatigue114 (34)16 (5)0000
Hypoalbuminemia50 (15)3 (1)0040 (12)2 (1)
Nausea81 (24)7 (2)0055 (16)6 (2)
Pericardial effusion39 (12)6 (2)6 (2)042 (12)9 (3)
Photosensitivity reaction100 (29)23 (7)00120 (35)23 (7)
Pleural effusion88 (26)18 (5)03 (1)95 (28)14 (4)
Thrombocytopenia38 (11)24 (7)21 (6)074 (22)37 (11)
Vomiting55 (16)4 (1)0028 (8)3 (1)
  • NOTE: Data shown are n (%). Shown are adverse events reported in at least 15% of all patients.

  • Abbreviation: Gr, grade.