Table 2.

Dose escalation and DLT summary.

IrinotecanAdavosertib
Dose levelmg/m2Number of patients enrolledNumber of patients evaluable for DLTNumber of patients with DLTType of DLT (n)
17050430
27065530
39065430
490851060
4 (PK)9085660
590110862Dehydration (2), Diarrhea (1), Hypotension (1)