Table 4.

Univariable and multivariable Cox proportional hazards models assessing association of genetic alterations with metastasis.

VariableUnivariableMultivariablea
HR (95% CI)P valueHR (95% CI)P value
CDKN1B deep deletion5.71 (1.23–26.61)0.0266.66 (1.26–35.22)0.026
CHD1 deep deletionb
PTEN deep deletion4.19 (0.94–18.62)0.0605.16 (0.97–27.48)0.055
FOXA1 mutation0.57 (0.08–4.29)0.5860.34 (0.04–2.76)0.310
SPOP mutation1.05 (0.30–3.62)0.9421.34 (0.34–5.32)0.678
TP53 mutation7.01 (2.01–24.41)0.0029.45 (2.20–40.55)0.002
  • aMultivariable models were adjusted for age at RP, PSA, RP grade group <4 or ≥4, and pathologic stage. RP grade group was analyzed as dichotomous variable due to low number of metastatic events per grade group.

  • bNo metastatic events were observed for CHD1 genetic alterations, hence HR and P values were not calculated.