Table 3.

Univariable and multivariable Cox proportional hazards models assessing association of PGA with metastasis.

VariableHR (95% CI)P valueHR (95% CI)P value
PGA (continuous)b1.11 (1.06–1.17)<0.0011.15 (1.07–1.23)<0.001
PGA (quartile)c
 ≤25th percentile1.00 (reference)1.00 (reference)
 25–50th percentile0.80 (0.07–8.88)0.8590.58 (0.05–6.43)0.655
 50–75th percentile5.28 (1.02–27.41)0.0483.31 (0.60–18.25)0.170
 >75th percentile14.43 (3.13–66.65)0.00113.45 (2.55–70.86)0.002
  • aMultivariable models were adjusted for age at RP, PSA, RP grade group <4 or ≥4, and pathologic stage. RP grade group was analyzed as dichotomous variable due to low number of metastatic events per grade group.

  • bPer 1% change in PGA.

  • c≤0.93% (≤25th percentile), 0.94%–3.74% (25th–50th percentile), 3.75%–9.35% (50th–75th percentile), and >9.35% (>75th percentile).