Table 2.

PGA in JHMI AA cohort (n = 205) and TCGA cohort (n = 313) by pathologic grade.

JHMI AA (n = 205)TCGA AA (n = 43)TCGA EA (n = 270)
PGA, median (IQR)P valuePGA, median (IQR)P valuePGA, median (IQR)P value
Total3.74 (0.93–9.35)6.48 (0.45–12.34)0.877a6.08 (1.74–11.71)
RP grade group<0.001b<0.001b<0.001b
 10.94 (0–4.21)0.61 (0.004–6.39)0.486a2.11 (0.05–4.99)
 21.87 (0–3.27)3.89 (0.09–7.53)0.480a4.68 (1.36–7.94)
 33.74 (0.94–10.28)9.57 (6.34–16.73)0.154a6.94 (2.68–11.38)
 48.41 (2.80–11.22)12.03 (8.86–15.51)0.780a13.74 (7.40–22.20)
 54.67 (0.94–9.35)26.2 (15.2–34.9)0.032b8.97 (3.53–17.90)
  • aP value signifies rank sum calculation to detect differences in PGA between TCGA AA and TCGA EA cohorts within each grade group.

  • bP value signifies Kruskal–Wallis calculation to detect differences in PGA between grade groups within each cohort.