Table 3.

Multivariable analysis of the association of DCISionRT categorical DS and clinicopathologic factors and treatment with total breast event risk.

TotBE
HR (95% CI)P
Categorical DS, elevated (> 3) vs. low (≤ 3)1.86 (1.00–3.46)0.048
Age, < 50 vs. ≥ 50 years1.24 (0.66–2.32)0.50
Presentation, clinical vs. screening1.16 (0.48–2.79)0.74
Excision no., 3+ vs. 1 or 21.11 (0.15–8.37)0.92
Grade, 3 vs. 1 or 20.89 (0.49–1.59)0.69
Necrosis, present vs. absent2.58 (1.14–5.84)0.023
Surgical margin, positive vs. negative1.74 (0.64–4.75)0.28
Endocrine therapy, yes vs. no0.39 (0.15–0.98)0.045
Radiotherapy, yes vs. no0.40 (0.21–0.77)0.006
  • Note: The association of categorical DS in combination with clinical, pathologic, and treatment factors with total (DCIS and invasive) breast event risk was assessed in the evaluable patient population by Cox proportional hazards analysis (n = 455). Negative surgical margin status was defined as no tumor cells identified at the inked resection margin. Endocrine therapy was based on prescribed course of therapy.

  • Abbreviations: TotBE, total breast events.