Table 2.

HER2-enriched patients: univariate DFS Cox regression analysis of genes found to be differentially expressed according to PIK3CA gene status.

All patients
GeneHR (95% CI)P
Upregulated in PIK3CA mut
ESR11.06 (0.95–1.19)0.300
PGR1.04 (0.96–0.93)0.490
MYC0.84 (0.64–1.09)0.193
MKI670.75 (0.49–1.17)0.203
CEP550.64 (0.39–1.04)0.073
MYBL20.72 (0.53–0.99)0.042
CD8A0.84 (0.68–1.05)0.118
CD2740.80 (0.57–1.12)0.197
PDCD10.81 (0.65–0.99)0.049
MAPT0.98 (0.88–1.19)0.801
Downregulated in PIK3CA mut
ERBB20.98 (0.81–1.20)0.873
GRB70.97 (0.80–1.18)0.773
TMEM45B1.31 (1.02–1.69)0.037
  • Abbreviations: CI, confidence interval; HR, hazard ratio.