Table 1.

Patients’ characteristics in the PIK3CA cohort according to PIK3CA gene status.

PIK3CA mutatedPIK3CA wild-typeTOT (PIK3CA cohort)
CharacteristicsN (%)N (%)N (%)P
Total174 (22%)629 (78%)803 (100%)
Age (years)
<60104 (60)393 (62)497 (62)
≥6070 (40)236 (38)306 (38)0.515
Median (Q1–Q3)57 (50–64)56 (48–64)56 (48–64)0.169
Menopausal status
Premenopausal49 (28)227 (36)276 (34)
Postmenopausal125 (72)401 (64)526 (66)0.050
AJCC Stage
I70 (40)259 (41)329 (41)
II77 (44)277 (44)354 (44)
III27 (16)91 (15)118 (15)0.936
N stage
N085 (49)343 (55)428 (53)
N1-N261 (35)191 (30)252 (31)
N328 (16)95 (15)123 (15)0.393
Hormone receptors
Negative41 (24)195 (31)236 (29)
Positive133 (76)434 (69)567 (71)0.057
Histologic grade
Grade 1–254 (31)172 (28)226 (28)
Grade 3118 (69)448 (72)566 (72)0.348
TILsMedian (Q1–Q3)5 (1–15)5 (1–15)5 (1–15)0.637
PAM50 Intrinsic subtype
LumA22 (24)64 (19)86 (20)
LumB8 (9)34 (10)42 (10)
HER2-enriched49 (53)183 (54)232 (54)
Basal-like2 (2)25 (7)27 (6)
Normal-like11 (12)35 (10)46 (11)0.358
Treatment arm
A long93 (53)312 (50)405 (50)
B short81 (47)317 (50)398 (50)0.369
  • Abbreviations: AJCC, American Joint Committee on Cancer; LumA, luminal A; LumB, luminal B; TILs, tumor-infiltrating lymphocytes.