Table 3.

DLTs.

CC-90011 doseAEAccompanying neutropeniaPlatelet transfusionDay of nadir on cycle 1
120 mgGrade 3 thrombocytopeniaGrade 2No15
120 mgGrade 3 thrombocytopeniaNoneNo15
120 mgGrade 4 thrombocytopeniaGrade 4Yes15
120 mgGrade 4 thrombocytopeniaGrade 2Yes12 and 15
80 mgaGrade 4 thrombocytopeniaGrade 4Yes25 (and C2D1)
80 mgaGrade 3 thrombocytopeniaGrade 3No15
60 mgGrade 4 thrombocytopeniaNoneYes15
  • Abbreviations: C, cycle; D, day.

  • aOriginally assigned to the 120-mg cohort at screening. Because of unacceptable toxicity (grade 3/4 thrombocytopenia) observed in 4 patients treated with 120 mg, the patients were reduced to 80 mg once per week.