Table 1.

Demographics of the cases used in the mCRC RWE testing set.

First-line FOLFOXFirst-line FOLFIRI
ActualModel predictionActualModel prediction
CharacteristicDBIBPaDBNo callIBPaDBIBPaDBNo callIBPa
Number of patients17923312050242262920629
Mean age (range)58.0 (31–85)57.9 (22–86)0.9357.5 (33–78)56.6 (31–80)58.5 (22–86)0.4460.9 (26–85)55.3 (32–77)0.0956.0 (32–77)62.8 (53–79)58.4 (26–85)0.47
Gender (F/M, %)45/5542/580.7343/5748/5243/570.7827/7348/520.1835/6533/6741/590.87
Primary tumor site, %b44/38/1853/29/180.1352/36/1252/36/1248/31/210.2135/54/1262/21/170.0465/30/583/17/031/45/240.04
BRAF, %c91/1/997/0/30.0292/0/898/2/094/0/60.03100/0/090/3/70.2490/5/583/0/17100/0/00.20
KRAS, %c45/1/5441/0/590.3642/0/5836/2/6245/0/550.0742/0/5828/0/720.3925/0/7550/0/5038/0/620.45
MSI, %d92/7/291/9/00.3584/13/292/6/295/5/0<0.0196/4/097/3/01.0095/5/0100/0/097/3/00.85
Second-line EGFRi, %e74/2671/290.5976/2474/2670/300.4688/1272/280.2575/2583/1783/170.78
  • Abbreviation: EGFRi, EGFR inhibitor.

  • aχ2 tests were used for categorical variables and Mann–Whitney U for nonnormally distributed age data.

  • bLeft/right/unknown or mix.

  • cNo pathogenic variant detected/indeterminate/pathogenic variant detected.

  • dStable/indeterminate/high.

  • eNo/yes.