Table 3.

KIT pathway alterations in mucosal melanomas of different anatomical sites

KIT mutationNRAS mutationBRAF mutationKIT IHCp-ERK IHCp-AKT IHC
Siten (%)n (%)n (%)n (%)n (%)n (%)
Vulva8/23 (35)0/23 (0)2/23 (9)13/23 (56)7/21 (33)13/21 (62)
Anorectum2/22 (9)1/22 (4.5)1/22 (4.5)6/22 (27)8/20 (40)11/20 (55)
Nasal cavity1/14 (7)2/14 (14)0/14 (0)4/14 (28)7/11 (64)9/11 (82)
Vagina0/7 (0)3/7 (43)0/7 (0)1/7 (14)4/7 (57)4/7 (57)
Penis1/5 (20)1/5 (20)1/5 (20)1/5 (20)1/5 (20)1/5 (20)
Total12/71 (17)7/71 (10)4/71 (6)25/71 (35)27/64 (42)38/64 (59)