Table 1.

Clinicopathologic characteristics of 71 primary mucosal melanomas

VariableNo. of patients (%)
Median age (range), y76 (41–95)
Median overall survival (range), mo28 (2–236)
Gender
 Male21 (29.6)
 Female50 (70.4)
Anatomical site
 Vulva23 (32.4)
 Anorectum22 (31.0)
 Nasal cavity14 (19.7)
 Vagina7 (9.9)
 Penis5 (7.0)
Clinical stage
 I41 (57.7)
 II6 (8.5)
 III5 (7.0)
 Data missing19 (26.8)
Thickness
 <10 mm26 (36.6)
 ≥10 mm29 (40.8)
 Data missinga16 (22.5)
Histogenetic type
 Mucosal lentiginous melanoma23 (32.4)
 Nodular melanoma17 (23.9)
 Superficial spreading melanoma3 (4.2)
 Mixedb2 (2.8)
 Unspecifiedc26 (36.6)
Histology
 Epithelioid36 (50.7)
 Spindle6 (8.5)
 Mixedd29 (40.8)
Mitoses (10 high-power fields)
 1–1035 (49.3)
 >1035 (49.3)
 Data missing1 (1.4)
Ulceration
 Present63 (88.7)
 Absent3 (4.2)
 Data missing5 (7.0)
Pigmentation
 Present49 (69.0)
 Absent22 (31.0)
  • aTumor thickness was sometimes not possible to evaluate because a free deep surgical margin was lacking.

  • bCombination of mucosal lentiginous melanoma and superficial spreading melanoma.

  • cTumors technically not classifiable because they were located in biopsies without any free surgical margins, which precluded adequate assessment of RGP.

  • dMixture of epithelioid and spindle cells.