Table 4.

Association between clinicopathologic characteristics and CHFR methylation status

VariableNo. of patients (%)
Methylation-negative or -low (n = 47)Methylation-high (n = 35)P2]
Age, y0.008
 <507 (47)8 (53)
 51–6013 (68)6 (32)
 61–7016 (84)3 (16)
 >7011 (38)18 (62)
Sex0.503
 Male22 (54)19 (46)
 Female25 (61)16 (39)
Tumor site0.002
 Proximal17 (40)25 (60)
 Distal30 (75)10 (25)
Tumor size0.585
 <5.023 (61)15 (39)
 >5.024 (55)20 (45)
AJCC primary tumor (T)0.649a
 T340 (56)31 (44)
 T47 (64)4 (36)
AJCC lymph node (N)0.110
 N017 (61)11 (39)
 N123 (66)12 (34)
 N27 (37)12 (63)
0.040
 N0/N140 (63)23 (37)
 N27 (37)12 (63)
AJCC stage0.654
 II17 (61)11 (39)
 III30 (56)24 (44)
Histologic grade0.214
 Well/moderate35 (54)30 (46)
 Poor/others12 (71)5 (29)
MLH1 expressionb0.928
 Positive26 (52)24 (48)
 Negative8 (53)7 (38)
  • aFisher's exact test.

  • bSixty-five cases of tissues were available for IHC of MLH1.