Table 4

Five-year estimated disease-specific survival (DSS) in 86 colon cancer patients undergoing curative surgery according to Dukes’ stage and different molecular patterns

Estimates of the 5-year DSS probability were calculated by the following formula: S(5 year, z) = [S0 (5 year)]exp(β1 z1 + β2 z2 + β3 z3), where S(5 year, z) is the 5-year survival probability for covariate vector z; z is a given covariate combination; z1, z2, and z3 are the values of p27, p53, and VEGF codified as negative (0) or positive (1), respectively; β1 is the regression coefficient for p27 and equals 2.4186; β2 is the regression coefficient for p53 and equals 1.3273; and β3 is the regression coefficient for VEGF and equals 0.9100; S0 is the estimated baseline DSS at 5 years for each stratum of Dukes’ stage.

p27ap53bVEGFcDukes’ stage
A (n = 21)B (n = 44)C + D (n = 18 + 3)
NNN94.590.879.2
NNP98.597.194.7
NPN97.895.692.1
PNN94.789.481.6
NPP93.787.478.3
PNP85.171.654.6
PPN78.260.339.9
PPP54.428.410.1
  • a N and P indicate colon cancers with p27 staining >20% or ≤20% of cells, respectively.

  • b N and P indicate colon cancers with p53 staining ≤10% or >10% of cells, respectively.

  • c N and P indicate colon cancers with VEGF staining ≤10% or >10% of cells, respectively.