Table 2

Genetic patterns to decide whether a local recurrence has developed from MRCa or precursor lesions (based on data from Fig. 1<$REFLINK> <$REFLINK> )

Patient no.Presence of tumor-related fieldComparison of genetic patterns of primary tumor and local recurrenceDecision origin of local recurrence
Yes/noIf yes, based onOther than LOH; similar markersLOH
Chance of similarity by coincidence (%)If similar, based on
1YesMSI at 13q, LOH at 3p, 17p, and 8pNANo similarityNAPrecursor lesion
2YesTP53 mutation, LOH at 9p and 17pNA9LOH at 3p and 13qPrecursor lesion
3NoMSI at 8p, TP53mutation<1LOH at 3p, 9p, and 17pMRC
4YesMSI at 8p, LOH at 9p and 17pTP53 mutation11LOH at 3p, no LOH at 13qMRC or precursor lesion
5YesMSI at 3p, LOH at 9pNA52No LOH at 13qPrecursor lesion
6YesTP53 mutation, LOH at 3p and 9pNA1LOH at 8p, no LOH at 17p, 18q, and 8pMRC or precursor lesion
7YesTP53 mutation, LOH at 17pMSI at 8p8LOH at 3p and 18qMRC or precursor lesion
8YesLOH at 9p, 17p, and 8pNA18LOH at 18qPrecursor lesion
9NoTP53 mutation<1LOH at 3p, 9p, 17p, and 8pMRC
10NoTP53 mutation, MSI at 3p and 18q1LOH at 17p, 8p, and 18q, no LOH at 13qMRC
11YesLOH at 9p14LOH at 3p and 17pPrecursor lesion
12NoTP53 mutation<1LOH at 3p, and 9p, no LOH at 17p, 13q, 18q, and 8pMRC
13NoTP53 mutation<1LOH at 3p, 9p, 17p, 13q, and 8p, no LOH at 18qMRC
  • MRC, mean residual cancer; LOH, loss of heterozygosity; MSI, microsatellite instability; NA, not applicable.