Table 1

Patient demographics and baseline disease

Pilot study n or mean (range)Recurrent study n or mean (range)
Number of patients2312
Age (years)50 (36–65)49 (30–79)
Body weight (kg)72 (46–105)72 (53–85)
Height (cm)169 (150–188)170 (151–181)
BSA (m2)a1.80 (1.46–2.11)1.83 (1.59–2.06)
Gender15/8 M/F9/3 M/F
KPS (%)90 (70–100)70 (30–100)
ECOG1 (1–2)1 (0–3)
Creatinine (μmol/liter)84 (61–108)84 (53–129)
GBM23 (100%)8 (67%)
AA/AOA04 (33%)
  • a BSA, body surface area; KPS, Karnofsky performance status; ECOG, eastern cooperative oncology group; GBM, glioblastoma multiforme; AA/AOA, anaplastic astrocytoma/anaplastic oligoastrocytoma.