Table 2

Human antibody response to the immunotoxin LMB-1a

Antibodies to LMB-1 were detected by a neutralization (Neut.) and ELISA on days 7, 14, 21, and 34 after the first dose of LMB-1. LMB-1 was given by i.v. injection on days 1, 3, and 5.

PatientPreaDay 7bDay 14bDay 21bDay 34c
Neut. assayELISA titerNeut. assayELISA titerNeut. assayELISA titerNeut. assayELISA titerNeut. assayELISA titer
1+1/2400+1/9000+1/6300
2+1/4000+1/60,000+1/100,000
3+nddnd
4+e1/1300e+1/800
51/7001/540+1/700+1/2500+1/3300
  • a Pre, assays done prior to starting LMB-1 treatment; −, absence of neutralizing antibodies or an ELISA titer less than twice the background; +, presence of anti-LMB-1 neutralizing antibodies. For the positive ELISA results, the titers are shown.

  • b ±2 days.

  • c ±8 days.

  • d nd, not done.

  • e Day 26.