Table 3

BRAF mutation and hMLH1 methylation status in HNPCCa

Patient no.MSIhMLH1 stainhMSH2 stainhMLH1 metBRAF mut
205b++
208b++
235b++
238b++
253b++
270b++
334b++
61++
73+++
96+++
196c+++
206+++
214+++
222c+++
233c+++
261c++
266c++
276+++
277++
279c+++
  • a HNPCC, hereditary nonpolyposis colorectal cancer; MSI, microsatellite instability; met, methylation; mut, mutant.

  • b Germ-line mutations of hMSH2 have been identified.

  • c Germ-line mutations of hMLH1 have been identified.