Table 2

APC gene mutations in MIN− SCRCs and MIN+ SCRCsa

No. of casesHotspot codon mutated (no. of cases)
MIN− SCRCs88
wt22 (25%)b
 Single APC mutation53
 Nonsense301450 (7), 1286 (2), 1294 (2), 876 (1), 1114 (1)
 Deletions131312 (3), 1467 (3), 1414 (2), 1471 (2), 1472 (1), 1506 (1)
 Insertions101558 (4), 1385 (2)
 Double APC mutation13
 Nonsense20876 (5), 1450 (3), 1114 (2)
 Deletions4859 (1), 1413 (1), 1472 (1), 1506 (1)
 Insertions21558 (2)
MIN+ SCRC11
wt7 (64%)b
 Single APC mutation32 deletions and 1 insertion
 Double APC mutation11 deletion and 1 insertion
  • a MIN, microsatellite instability; SCRC, sporadic colorectal cancer.

  • b MIN− SCRCs versus MIN+ SCRCs, P = 0.0079.