Table 6

Multivariate survival analyses

ParameterMultivariate HRa,b (95% CI)P
Sp1 expression
 Negative1.00 (referent)
 Weak2.07 (0.90–4.77)0.087
 Strong3.54 (1.20–10.42)0.022
VEGF expression
 Negative1.00 (referent)
 Weak0.86 (0.37–1.99)0.72
 Strong0.88 (0.32–2.46)0.81
AJCC stage
 I1.00 (referent)
 II1.57 (0.53–4.65)0.416
 III5.97 (2.10–16.98)0.001
 IV7.55 (2.11–27.02)0.002
Resection status
 R01.00 (referent)
 R1 and R22.11 (0.88–5.05)0.093
Lauren’s classification
 Intestinal1.00 (referent)
 Diffuse0.78 (0.36–1.68)0.526
WHO grade
 1–21.00 (referent)
 3–40.67 (0.39–1.84)0.668
Age (continuous variable)1.00 (0.97–1.02)0.843
  • a HRs estimated using multivariate Cox proportional hazards modeling.

  • b HR, hazard ratio; CI, confidence interval; VEGF, vascular endothelial growth factor; AJCC, American Joint Committee on Cancer.