Table 1

Clinicopathological and hypermethylation detection data in tumors and aspirate fluids of breast cancer patients

TNM, tumor-node-metastasis staging classification, all tumors were M0; stage, Stage Grouping, American Joint Committee on Cancer; mf, multifocal; grade, histologic grade; cytology, cytology of nipple aspirate fluid; Meth.Gene, hypermethylated gene(s) in tumor used as target in paired aspirate fluid DNA; Detected, hypermethylation of identical gene(s) detected in aspirate fluid DNA, Y, yes or N, no.

PatientAge (yrs)TNMStageSize (cm)GradeCytologyMeth.GeneDetected
144TisN000.252MalignantGSTP1,p16Y,Y
242TisN000.62NormalRARβ,RASSF1AN,N
350TisN000.92NormalRARβY
446TisN001.12BenignRASSF1AY
551TisN00mf2NormalRASSF1AY
660TisN00mf2Normalp14Y
747TisN00mf3MalignantGSTP1,p14Y,Y
875T1N0I0.21NormalRARβY
943T1N0I0.92MalignantGSTP1Y
1051T1N0I13NormalRASSF1AN
1156T1N0I1.72NormalRARβY
1260T1N0I2.02NormalRARβY
1346T2N0IIA33MalignantGSTP1N
1446T2N1IIB0.83Malignantp14Y
1547T2N1IIB1.23MalignantGSTP1,p16Y,Y
1665T2N1IIB2.43MalignantRARβ,p16N,N
1753T2N1IIB3.53Malignantp16Y
1842T2N1IIB43MalignantGSTP1,RASSF1AY,Y
1935T2N1IIB4.53MalignantRARβ,p14Y,Y
2034T2N1IIB4.53MalignantDAP-KY
2143T2N1IIBmf3Malignantp16Y
2231T3N1IIIA72MalignantGSTP1,p14Y,Y